Ukuhlanganiswa Kwesayithi Okuthile Faka Ngokunembile Izakhi Zofuzo Eziqondiwe Kundawo Eshisayo Ekhethekile
Ukuhlanganiswa okuqondene nesayithi kuyinqubo yokwenza iwebhusayithi ngokwezifiso noma uhlelo lokusebenza ukuze lilingane nezidingo ezihlukile zewebhusayithi ethile noma uhlelo lokusebenza.Kuyinqubo ebandakanya ukwenza izinguquko kukhodi ekhona kanye nesakhiwo sesizindalwazi noma isicelo ukuze siyenze isebenze kahle futhi iphumelele izidingo ezithile zesayithi.Ukuhlanganiswa okuqondene nesayithi kungasetshenziswa ukuze kulungiswe izici ezikhona, kwengeze izici ezintsha, futhi kuthuthukiswe ukusebenziseka kukonke kwewebhusayithi noma uhlelo lokusebenza.Lokhu kuwusizo ikakhulukazi kumabhizinisi anamawebhusayithi amaningi noma izinhlelo zokusebenza ezidinga ukuhlanganiswa namanye ukuze anikeze amakhasimende awo ulwazi olungenazihibe.
I-Pro-antibody Design Platform enikwe amandla yi-AI
I-AlfaCap™
I-AI enikwe amandla i-Site-Specific Integration Cell Line Development Platform
I-Al-enabled Cell Culture Media Development Platform
Ukuhlanganiswa okuqondene nesayithi kumaseli e-CHO kuyinqubo esetshenziselwa ukwethula isakhi sofuzo endaweni echazwe kahle ku-genome yamaseli e-Chinese hamster ovary (CHO).Le nqubo ihlanganisa ukusebenzisa i-enzayimu ye-recombinase eqondene nesayithi ukuze iqondise ukulandelana okuthile ku-CHO cell genome bese ihlanganisa isakhi sentshisekelo ekulandeleni okuhlosiwe.Le ndlela ivumela ukulawula okunembe kakhudlwana ekufakweni kwezakhi zofuzo ku-CHO cell genome futhi ingasiza ukugwema ukuhlanganiswa okungahleliwe, okungaba nemiphumela elimazayo kumaseli.Izinzuzo eziyinhloko zale ndlela ukuthi inikeza ukulawula okukhulu nokunemba phezu kwenqubo yokuhlanganisa, kanye nezinga elikhulu lokuzinza kwesakhi ngokuhamba kwesikhathi.Ukwengeza, le ndlela ingasetshenziswa ukwethula izakhi zofuzo eziningi ezindaweni ezahlukene ngaphakathi kweseli, okuyenza ibe ithuluzi elinamandla lokuxhaphaza izakhi zofuzo.
Iqondise ama-vector
Ama-vectors aqondisayo asetshenziselwa ukudala izinto eziphilayo eziguqulwe izakhi ngokwethula ukulandelana okuqondile kwe-DNA ku-genome yazo.Ngokuvamile akhiwa umaka wofuzo ovumela ukuhlonzwa kwamaseli ashintshiwe, umaka ongakhethwa ovumela ukukhethwa kwamaseli ashintshiwe, kanye nesifunda sokuhlanganisa kabusha esifana neso esivumela ukuhlanganiswa kokulandelana kwe-DNA okufunayo kugenome yento ephilayo eqondiwe.Ama-vector aqondisayo avame ukusetshenziswa ekukhishweni kwezakhi zofuzo, kuma-gene knockin, ukuhlela izakhi zofuzo, nezinye izinhlobo zobunjiniyela bofuzo.
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